- Barrier Breakdown Enables PAMP Leakage
– Disruption of gut, oral, or skin epithelial barriers allows bacterial fragments like LTA and PGN to enter systemic circulation, even in the absence of active infection. - Silent Driver of Chronic Inflammation
– This low-level, continuous translocation of bacterial PAMPs fuels persistent immune activation, contributing to “sterile inflammation” seen in aging, metabolic syndrome, and neurodegeneration.